Publications

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FROM THE LAB

Chung HL*, Ye Q*, Park YJ, Zuo Z, Mok JW, Kanca O, Tattikota SG, Lu S, Perrimon N, Lee HK#, Bellen HJ#. Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation. Cell Metab. 2023 Apr 14;. doi: 10.1016/j.cmet.2023.03.022. [Epub ahead of print] PubMed PMID: 37084732; NIHMSID:NIHMS1891842. (#Co-corresponding)

Wang CY, Zuo Z, Jo J, Kim K, Madamba C, Ye Q, Jung SY, Bellen HJ, Lee HK. CK2α-dependent regulation of Wnt activity governs white matter development and repair. PNAS 2023. 120 (35) e2304112120;

Ye Q, Jo J, Wang CY, Oh H, Choy TJ, Kim K, D’Alessandro A, Reshetnyak YK, Jung SY, Chen Z, Marrelli SP, Lee HK. Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a NO-CCL2-CCR2 pathway.bioRxiv 2023.04.03.535167; doi: https://doi.org/10.1101/2023.04.03.535167

Cristobal CD and Lee HK. Development of myelinating glia: An overview. Glia, 2022; 70( 12), 2237– 2259. https://doi.org/10.1002/glia.24238. Epub 2022 Jul 4. Review. PubMed PMID: 35785432; PubMed Central PMCID: PMC9561084. 

Cristobal CD*, Wang CY*, Zuo Z, Sm.ith JA, Lindeke-Myers A, Bellen HJ, Lee HK. Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin. J Neurosci. 2022 Mar 2;42(9):1679-1691. doi: 10.1523/JNEUROSCI.1517-21.2022. Epub 2022 Jan 31. PubMed PMID: 35101966; PubMed Central PMCID: PMC8896627. 

Jo J, Woo J, Cristobal CD, Choi JM, Wang CY, Ye Q, Smith JA, Ung K, Liu G, Cortes D, Jung SY, Arenkiel BR, Lee HK. Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function. EMBO Reports 2021 Oct 11:e53200. doi: 10.15252/embr.202153200. PMID: 34633730. PubMed Central PMCID: PMC8647146. 

Cristobal CD, Ye Q, Jo J, Ding X, Wang CY, Cortes D, Chen Z, Lee HK. Daam2 couples translocation and clustering of Wnt receptor signalosomes through Rac1. J Cell Sci. 2021 Jan 25;134(2). doi: 10.1242/jcs.251140. PubMed PMID: 33310913; PubMed Central PMCID: PMC7860116

Lopez-Silva TL*, Cristobal CD*, Edwin Lai CS, Leyva-Aranda V, Lee HK#, Hartgerink JD#. Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury. Biomaterials. 2021 Jan;265:120401. doi: 10.1016/j.biomaterials.2020.120401. Epub 2020 Sep 19. PubMed PMID: 33002786; PubMed Central PMCID: PMC7669633. (#Co-corresponding)

Ding X, Jo J, Cristobal DC, Zuo Z, Wang CY, Wirianto M, Ye Q, Lindeke-Myers A, Choi JM, Mohila CA, Kawabe H, Jung SY, Bellen H, Yoo, SH, Lee HK. The Daam2-VHL-Nedd4 Axis Governs Developmental and Regenerative Oligodendrocyte Differentiation. Genes & Dev. 2020 September ; 1 (34(17-18)): 1177-1189. Pubmed PMID: 32792353. PubMed Central PMCID: PMC7462057. 

Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK#, Deneen B#. Daam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 Oct 20;6. doi: 10.7554/eLife.31926. PubMed PMID: 29053101; PubMed Central PMCID: PMC5650470. (#Co-corresponding)

Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SP, Mohila C, Deneen B. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. 2015 October ; 63 (10): 1840-9. Pubmed PMID: 25946682.

Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SP, Deneen B. Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 May 18; 85 (6): 1227-43. Pubmed PMID: 25754822.

Kang P*, Lee HK*, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 April 12; 74 (1): 79-94. Pubmed PMID: 22500632.

Lee HK, Deneen B. Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Dev Cell. 2012 January 17; 22 (1): 183-96. doi: 10.1016/j.devcel.2011.10.025. Epub 2012 Jan 5. PubMed PMID: 22227309; PubMed Central PMCID: PMC3264735. 

COLLABORATIONS

Kim E, Kim YJ, Ji Z, Kang JM, Wirianto M, Paudel KR, Smith JA, Ono K, Kim JA, Eckel-Mahan K, Zhou X, Lee HK, Yoo JY, Yoo SH, Chen Z. ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer. Cell Death Dis. 2022 Apr 19;13(4):374. doi: 10.1038/s41419-022-04826-5. PubMed PMID: 35440077; PubMed Central PMCID: PMC9018867.  

Wirianto M, Wang CY, Kim E, Koike N, Gomez-Gutierrez R, Nohara K, Escobedo G Jr, Choi JM, Han C, Yagita K, Jung SY, Soto C, Lee HK, Morales R, Yoo SH, Chen Z. The clock modulator Nobiletin mitigates astrogliosis-associated neuroinflammation and disease hallmarks in an Alzheimer's disease model.FASEB J. 2022 Mar;36(3):e22186. doi: 10.1096/fj.202101633R. PubMed PMID: 35120261; PubMed Central PMCID: PMC8887996.  

Jo YR, Kim HR, Jang SY, Go H, Song MY, Park DK, Oh Y, Jo J, Shin YK, Lee SJ, Cheon SM, Lee HK, Lee KE, Kim YH, Park HT. Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments. FASEB J. 2021 Jan;35(1):e21225. doi: 10.1096/fj.202001366RR. PubMed PMID: 33337568. 

Wirianto M, Yang J, Kim E, Gao S, Paudel KR, Choi JM, Choe J, Gloston GF, Ademoji P, Parakramaweera R, Jin J, Esser KA, Jung SY, Geng YJ, Lee HK, Chen Z, Yoo SH. The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function. Cell Rep. 2020 Sep 15;32(11):108140. doi: 10.1016/j.celrep.2020.108140. PubMed PMID: 32937135; PubMed Central PMCID: PMC8299398.  

Kim HK, Lee SY, Koike N, Kim E, Wirianto M, Burish MJ, Yagita K, Lee HK, Chen Z, Chung JM, Abdi S, Yoo SH. Circadian regulation of chemotherapy-induced peripheral neuropathic pain and the underlying transcriptomic landscape. Sci Rep. 2020 Aug 14;10(1):13844. doi: 10.1038/s41598-020-70757-w. PubMed PMID: 32796949; PubMed Central PMCID: PMC7427990. 

Chung HL, Wangler MF, Marcogliese PC, Jo J, Ravenscroft TA, Zuo Z, Duraine L, Sadeghzadeh S, Li-Kroeger D, Schmidt RE, Pestronk A, Rosenfeld JA, Burrage L, Herndon MJ, Chen S, Shillington A, Vawter-Lee M, Hopkin R, Rodriguez-Smith J, Henrickson M, Lee B, Moser AB, Jones RO, Watkins P, Yoo T, Mar S, Choi M, Bucelli RC, Yamamoto S, Lee HK, Prada CE, Chae JH, Vogel TP, Bellen HJ. Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms. Neuron. 2020 May 20;106(4):589-606.e6. doi: 10.1016/j.neuron.2020.02.021. Epub 2020 Mar 12. PubMed PMID: 32169171; PubMed Central PMCID: PMC7289150. 

Laug D, Huang TW, Huerta NAB, Huang AY, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel BR, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen B. Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury. J Clin Invest. 2019 Oct 1;129(10):4408-4418. doi: 10.1172/JCI127492. PubMed PMID: 31498149; PubMed Central PMCID: PMC6763246. 

Liu G, Froudarakis E, Patel JM, Kochukov MY, Pekarek B, Hunt PJ, Patel M, Ung K, Fu CH, Jo J, Lee HK, Tolias AS, Arenkiel BR. Target specific functions of EPL interneurons in olfactory circuits. Nat Commun. 2019 Jul 29;10(1):3369. doi: 10.1038/s41467-019-11354-y. PubMed PMID: 31358754; PubMed Central PMCID: PMC6662826.  

Suh JH, Lai L, Nam D, Kim J, Jo J, Taffet GE, Kim E, Kaelber JT, Lee HK, Entman ML, Cooke JP, Reineke EL. Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis. J Biol Chem. 2017 Dec 29;292(52):21643-21652. doi: 10.1074/jbc.M117.804740. Epub 2017 Nov 10. PubMed PMID: 29127200; PubMed Central PMCID: PMC5766961. 

Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis YM, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee SK, Mohila CA, Deneen B. Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci. 2017 Nov;20(11):1520-1528. doi: 10.1038/nn.4638. Epub 2017 Sep 11. PubMed PMID: 28892058; PubMed Central PMCID: PMC5919190. 

John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar;20(3):396-405. doi: 10.1038/nn.4493. Epub 2017 Feb 6. PubMed PMID: 28166219; PubMed Central PMCID: PMC5824716. 

Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen B. Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 Nov 23;36(47):11904-11917. doi: 10.1523/JNEUROSCI.1658-16.2016. PubMed PMID: 27881777; PubMed Central PMCID: PMC5125245.